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Filtered Search Results
Medchemexpress LLC (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro | 1207456-00-5 | 98.3% | 380.35 | 200 MG
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This product is an enantiomer of Talazoparib, functioning as a PARP1 inhibitor with an IC50 of 144 nM. It is intended for research use only.
- Inhibits PARP1.
- Shows cellular PARylation inhibition.
- Demonstrates cytotoxicity against BRCA2-deficient cells.
- Potentiates temozolomide-induced cytotoxicity.
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Medchemexpress LLC Dextran T7 (MW 7,000) | 9004-54-0 | 5600-8400 | 10 G
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Dextran T7 (Dextran 7; Dextran D7) (MW 7,000) is a polymer of anhydroglucose with an average molecular weight of 7000. It exhibits good biodegradability and biocompatibility, making it suitable for use in food, pharmaceutics, cosmetics, and research.
- Used as an encapsulation material for superparamagnetic magnetite nanoparticles, which can be formulated into a liver contrast agent for magnetic resonance imaging.
- Can be conjugated with cytosine deaminase (CDA) from Aspergillus niger to enhance the enzyme's structural stability, resistance to protease degradation, and anti-proliferative activity.
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Medchemexpress LLC Dihydroethidium | 104821-25-2 | 98.83% | 25 MG
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Dihydroethidium, also known as DHE, is a peroxide indicator that penetrates cell membranes to form a fluorescent protein complex with blue fluorescence. After entering cells, it primarily localizes in the cell membrane, cytoplasm, and nucleus, with the strongest staining effect in the nucleus. It produces inherent blue fluorescence and, upon dehydrogenation, combines with RNA or DNA to produce red fluorescence.
- Peroxide indicator
- Penetrates cell membranes
- Forms a fluorescent protein complex with blue fluorescence
- Primarily localized in cell membrane, cytoplasm, and nucleus, strongest staining in the nucleus
- Produces inherent blue fluorescence (Ex 370 nm, Em 420 nm)
- Combines with RNA or DNA after dehydrogenation to produce red fluorescence (Ex 300 nm, Em 610 nm; 535 nm also usable for excitation)
- Solid form
- Pale purple to light pink color
- For research use only
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Medchemexpress LLC 7-Methylisatin | 1127-59-9 | 161.16 | 10 G
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7-Methylisatin is a derivative of Isatin and can be utilized as a molecular block for biochemical assay reagents.
- Derivative of Isatin
- Can be utilized as a molecular block
- For research use only
- Store at room temperature for 3 years; in solvent, -80°C for 2 years; -20°C for 1 year
- Soluble in DMSO
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000431998 MHI-148 25MG
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Medchemexpress LLC Deferoxamine (mesylate) (Standard) | 138-14-7 | 99.8% | 25 MG
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Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator that binds to Fe(III) and many other metal cations. It is widely used to reduce iron accumulation and deposition in tissues. It upregulates HIF-1α levels with good antioxidant activity and also shows anti-proliferative activity, inducing apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases, as well as anti-cancer and anti-COVID-19 research.
- Binds to Fe(III) and many other metal cations.
- Reduces iron accumulation and deposition in tissues.
- Upregulates HIF-1α levels.
- Exhibits good antioxidant activity.
- Shows anti-proliferative activity.
- Induces apoptosis and autophagy in cancer cells.
- Used in studies of diabetes and neurodegenerative diseases.
- Used in anti-cancer and anti-COVID-19 research.
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Medchemexpress LLC MNS (NSC 170724), 5-(2-nitrovinyl)benzodioxole | 1485-00-3 | 99.55% | C9H7NO4 | 200 MG
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MNS (NSC 170724), a beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. It inhibits Src, Syk, and FAK, and is cytotoxic to various cell types. This compound also inhibits NLRP3 inflammasome and β1 integrin.
- Acts as a tyrosine kinase inhibitor.
- Functions as a broad-spectrum antiplatelet agent.
- Inhibits Src, Syk, and FAK.
- Inhibits NLRP3 inflammasome.
- Inhibits β1 integrin.
- Exhibits cytotoxicity to various cell types.
- Completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation.
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Medchemexpress LLC 5-Bromoisoquinoline | 34784-04-8 | 208.06 | 50 G
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5-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. It is also a synthetic intermediate useful for pharmaceutical synthesis.
- Biochemical reagent
- Used as a biological material or organic compound
- Applicable in life science-related research
- Synthetic intermediate for pharmaceutical synthesis
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Medchemexpress LLC 5-Bromoisoquinoline | 34784-04-8 | 208.06 | 10 G
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5-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is also described as a synthetic intermediate useful for pharmaceutical synthesis.
- Can be used as a biochemical reagent
- Useful as a biological material or organic compound for life science related research
- Acts as a synthetic intermediate for pharmaceutical synthesis
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Medchemexpress LLC Diflucortolone valerate | 59198-70-8 | 478.57 | 200 MG
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Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases. It is a potent corticosteroid esterified with valeric acid, which helps reduce swelling, itching, and redness. It is for research use only and not sold to patients. The product appears as a white to off-white solid.
- Powerful corticosteroid
- Used for research of various skin diseases
- Esterified with valeric acid
- Helps reduce swelling, itching, and redness
- Appears as a white to off-white solid
- For research use only
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Medchemexpress LLC Cilazapril monohydrate | 92077-78-6 | 99.9% | C22H33N3O6 | 1 ML
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Cilazapril monohydrate is an orally active prodrug of the angiotensin-converting enzyme (ACE) inhibitor Cilazaprilat. It reduces plasma ACE activity and can be used in the research of hypertension (including essential and renal hypertension) and congestive heart failure. This product is for research use only and not sold to patients.
- Orally active prodrug
- Reduces plasma ACE activity
- Used in research of hypertension
- Used in research of congestive heart failure
- Evokes significant plasma ACE inhibition
- Reduces blood pressure in dogs with renal hypertension
- Improves postischemic myocardial function in hyperthyroid rats
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Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.9% | 25 MG
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Danofloxacin mesylate is a fluoroquinolone veterinary drug known for its broad-spectrum bactericidal activity. It primarily functions by inhibiting the DNA gyrase of bacteria and also acts as a substrate for ATP-dependent efflux transporters such as P-gp and MRP2. This compound is intended for research use only.
- Fluoroquinolone veterinary drug
- Broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Substrate for ATP-dependent efflux transporters (P-gp and MRP2)
- Exhibits asymmetric transport across Caco-2 cells
- Inhibits bovine bacterial respiratory pathogens
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Medchemexpress LLC 5-Bromoisoquinoline | 34784-04-8 | 208.06 | 500 MG
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This compound serves as a valuable biochemical reagent and synthetic intermediate for life science research applications, particularly in pharmaceutical synthesis. It is a solid, white to off-white in appearance, with a molecular weight of 208.06. This product is intended strictly for research purposes and is not for human use.
- Biochemical reagent for life science applications.
- Useful as an organic compound in research.
- Synthetic intermediate for pharmaceutical development.
- High purity.
- Available in various quantities to suit different research needs.
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Medchemexpress LLC Tigecycline | 220620-09-7 | 99.95% | 200 MG
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Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. It has been shown to inhibit AML2 and HL-60 cells, with specific IC50 values. Its activity extends to bacterial strains, demonstrating a mean inhibitory concentration (MIC) of approximately 125 ng/mL for E. coli (MG1655 strain), and MIC50 and MIC90 values of 1 and 2 mg/L, respectively, for Acinetobacter baumannii.
- Broad-spectrum glycylcycline antibiotic
- Inhibits AML2 and HL-60 cells in vitro
- Demonstrates activity against E. coli and Acinetobacter baumannii
- Light yellow to orange solid appearance
- Derived from microorganisms
- Reduced tumor volume and weight in an AML xenograft model
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Medchemexpress LLC Dbco-amine (Gmp) | 1255942-06-3 | 276.33 | 500 MG
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DBCO-amine (GMP) is a GMP grade click chemistry reagent that contains a DBCO group. This group enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that possess azide groups. It is utilized in the synthesis of antibody-drug conjugates (ADCs).
- Gmp grade
- Click chemistry reagent
- Contains a DBCO group for SPAAC reactions
- Used in the synthesis of antibody-drug conjugates (ADCs)
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