Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,901 – 3,915 of 5,528 results

3,901

Medchemexpress LLC TMP269 | 1314890-29-3 | 98.2% | 514.52 | 200 MG

TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor, targeting HDAC4, HDAC5, HDAC7, and HDAC9. It is intended for research use only. TMP269 modulates cell cycle progression and enhances cytotoxicity in certain cell lines, without affecting class I or IIb HDACs. It has also shown antiangiogenic effects in vivo.

Novel and selective class IIa histone deacetylase (HDAC) inhibitor
Targets HDAC4, HDAC5, HDAC7, and HDAC9
Modulates cell cycle progression in IEC-18 intestinal epithelial cells
Enhances CFZ-induced cytotoxicity in MM cell lines
No inhibitory effects on class I or IIb HDACs
Demonstrates antiangiogenic effects in vivo

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3,902

Apexbio Technology LLC Olmutinib (HM61713, BI 1482694) 1353550-13-6 200mg

Olmutinib (HM61713 BI 1482694 CAS 1353550-13-6) is an irreversible mutant-selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It covalently binds to a cysteine residue near the EGFR kinase domain particularly targeting mutant forms such as L858R/T790M and exon 19 deletion In cellular assays Olmutinib demonstrated potent inhibition of EGFR signaling in NSCLC cell lines H1975 (L858R/T790M GI50 9 2 nM) and HCC827 (exon 19 deletion GI50 10 nM) while showing low activity against wild-type EGFR cell lines It exhibits prolonged inhibitory effects ( 24 h) on EGFR activity and demonstrates in vivo antitumor efficacy in xenograft models without significant adverse effects Olmutinib serves as a tool for studying third-generation EGFR TKI resistance mechanisms in NSCLC

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3,903

Apexbio Technology LLC U0126 200mg

U0126 (CAS 109511-58-2) is a selective non-ATP competitive inhibitor of the MAPK/ERK kinase (MEK1/2) pathway interfering with downstream ERK1/2 activation By inhibiting MEK1/2 activity U0126 modulates cellular processes including proliferation differentiation and survival Additionally U0126 has been reported to suppress autophagy and mitophagy pathways This compound is widely used in biomedical research to investigate MAPK signaling dynamics as well as to explore the regulation of autophagic and mitochondrial quality control mechanisms in various cell models